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인공지능이 논문을 이해한다고?

페이스북에서 우연히 GPT가 미쳐돌아간다는 포스팅을 봤다. 이제 챗GPT가 이미지를 입력으로 받을 수 있는데, 논문 그림을 무작위로 업로드했더니 그림을 이해하고 설명을 하더라는 것이다. 설마하면서 구글 바드에 들어가서 이것저것 업로드를 해보다 깜짝 놀랐다. 완벽하지는 않지만 논문의 그림을 올리면 그걸 대충 이해하고 설명하려 든다. 이런 세상이 오고야 말았다. 아래는 그 결과다. 일단 여기까지 하고, 조만간 상세한 테스트를 해볼 생각이다.

Park, A., Croset, V., Otto, N., Agarwal, D., Treiber, C. D., Meschi, E., … & Waddell, S. (2022). Gliotransmission of D-serine promotes thirst-directed behaviors in Drosophila. Current Biology32(18), 3952-3970.

위 논문의 그래픽 초록을 바드에게 이미지로 입력했고, 아래와 같은 출력을 받았다.

The graphical abstract you sent shows the role of gliotransmission of D-serine in promoting thirst-directed behaviors in Drosophila.

The two flies on the left represent sated flies, while the two flies on the right represent thirsty flies. The arrows represent the flow of information and signaling molecules.

The blue text represents the key findings of the study:

  • Water deprivation primarily altered the glial transcriptome.
  • Astrocytic expression of the astray-encoded phosphoserine phosphatase is required for bi-directional regulation of water consumption.
  • Astray synthesizes the gliotransmitter D-serine, and vesicular release from astrocytes is required for drinking.
  • D-serine action requires binding to neuronal NMDA-type glutamate receptors.

The study also found that the proportion of astrocytes that are themselves activated by glutamate increases with water deprivation. This suggests that thirst elevates astrocytic D-serine release, which awakens quiescent glutamatergic circuits to enhance water procurement.

Overall, the graphical abstract shows that gliotransmission of D-serine plays a critical role in thirst-directed behaviors in Drosophila.

Here is a more detailed explanation of the different components of the graphical abstract:

  • Sated flies: These flies have a normal water balance and do not experience thirst.
  • Thirsty flies: These flies have a negative water balance and experience thirst.
  • Astrocytes: These are glial cells that play a variety of roles in the brain, including regulating water homeostasis.
  • Astray: This is a phosphoserine phosphatase enzyme that is expressed in astrocytes and is required for the synthesis of D-serine.
  • D-serine: This is a gliotransmitter that is released from astrocytes and can activate NMDA-type glutamate receptors on neurons.
  • NMDA-type glutamate receptors: These are excitatory glutamate receptors that play a role in a variety of brain functions, including learning and memory.

The graphical abstract shows that water deprivation activates astrocytes to release D-serine. D-serine then binds to NMDA-type glutamate receptors on neurons, which activates these neurons and promotes thirst-directed behaviors.

This research is important because it provides new insights into the molecular and cellular mechanisms of thirst. It also suggests that D-serine-based therapies could be used to treat thirst disorders in humans.

심지어 해당 논문의 링크까지 찾아 붙힌걸 보니, 기존 구글 이미지 검색과도 연동이 되는 듯 하다. 이 정도면 이제 진짜 논문을 읽지 않고 논문그림만 바드에게 주고 설명하라고 하면 될 지도 모르겠다. 세상이 정말 빠르게 변하고 있다.